She begins as a child, obtains her violin diploma with maximum marks and graduating magna cum laude at the Florence “L. Cherubini” Conservatoire and continues her education with Ilya Grubert, Zenaida Gilels and Pavel Vernikov; furthermore she attends the Special Class for “ “Concertmaster” with Giulio Franzetti (Teatro alla Scala Concertmaster)

She won several national and international competitions, won the ORT (Orchestra della Toscana) violin contest and has been member of the Orchestra for 23 years.

She performs as Concertmaster with the Orchestra Sinfonica Siciliana, with the Orchestra del Teatro Goldoni di Livorno and the Orchestra Mozart e Milano, as Principal Assistant Concertmaster and Leader of Second Violins with the Orchestra Toscanini di Parma, the Orchestra della Toscana, Gli Archi della Scala and I Solisti di Pavia.

Concertmaster of the Pino Donaggio Orchestra for his soundtracks recordings.

She performs with the best Conductors and Soloists: Mario, Brunello, Maxim Vengerov, Giovanni Sollima, Riccardo Chailly, Myung-whun Chung, Daniele Gatti, Luciano Berio, Salvatore Accardo, Patrick Gallois and Daniel Harding…

She has collaborated with the Orchestra Sinfonica della Rai di Roma, Orchestra del Teatro Comunale di Bologna, Orchestra da Camera di Padova e del Veneto, Orchestra della Toscana, Orchestra Sinfonica A. Toscanini, Orchestra Haydn di Bolzano e Trento, Orchestra del Maggio Musicale Fiorentino. 

She performs as soloist and in many chamber groups and ensembles. 

Founder of "Trio d'archi di Firenze" , Carlo Boccadoro dedicated her the “Trio d'Archi”.

She plays in duo violin-piano with Andrea Dindo and Marco Grisanti and she's a member of the ORT Strings Quintett since its foundation.

As a guest in important Musical Festivals such as: Biennale di Venezia, Concerti del Quirinale dalla Cappella Paolina (live RADIO3RAI Italian Radio Television), New York Carnegie Hall, Hong Kong Arts Festival, Tuscan Sun Festival (Teatro La Pergola), Florence Festival ”Play it” (2014 Abbiati Price), Performing Art Center di Pechino, Tanzania Republic Presidency, Menuhin Festival Musiksommer, Maggio Musicale Fiorentino, Teatro Bellas Artes Festival Mexico, Festival d'Avignon, Bologna Musica Insieme, Unione Musicale Torino, Rome IUC La Sapienza, Trentino I Suoni delle Dolomiti, Stresa Festival, Napoli Spinacorona Festival, Bari Teatro Petruzzelli Season, Opatija Kvarner Festival. 

She has collaborated as solo violin with, Giorgio Barberio Corsetti and Mario Martone in a production of “Histoire du Soldat” di Igor Strawinsky in the Festival di Avignone with Ninetto Davoli; principal violin in 'Medea' di Benda with Maddalena Crippa; she has been working with Tullio Solenghi on a project dedicated to W.A.Mozart and the K563 Divertimento for violin, viola and cello execution. With Stefania Rocca, Andrea Dindo and Giampiero Sobrino, she created a violin, clarinet and piano French music project; with Lucrezia Lante della Rovere, Ennio Morricone, Nicola Piovani, Tan Dun, Nanni Moretti, Luis Bacalov, Franco Battiato, Lucio Dalla, Stefano Bollani, Riz Ortolani, Mauro Pagani, Uri Caine, Ludovico Einaudi, Noa…

With Andrea Dindo and Renato Carpentieri she has been performing in a project dedicated to the L.Van Beethoven Kreutzer Sonata.

She has been on tour in Japan, China, USA (New York Carnegie Hall), Argentina, Brazil, Mexico, Uruguay, Chile, Perù, Tanzania, Austria, Croatia, Belgium, France, Germany, Portugal, Spain, Monaco and Switzerland. 

She has recorded for the RAI (Radio Televisione Italiana) and recorded for Fonit Cetra, Sony Classical, Ricordi, Arts-Pilz, Phoenix Classics and Naxos as soloist, as first violins leader and in chamber ensembles, achieving prizes (Abbiati Prize) and acknowledgment from the critics ( Five Stars Classic CD).

She has recorded Viotti Violin Duets with Franco Mezzena for Luna Rossa Classic/Corrado Productions. These recordings have been included in the Ridley Scott movie “Napoleon” soundtrack. 

She has played premier performances dedicated to her by contemporary composers like: Pino Donaggio, Eduardo Bruni, Carlo Boccadoro, Bruno Moretti, Vincenzo Saldarelli…

She recently took part as Medit Orchestra Concertmaster in The Manhattan Transfer Big Farewell Tour.

She teaches violin since many years at the Milano, Cuneo, Campobasso, Modena and Bologna Conservatoriums. She is a Tutor at the 2015 Arezzo International Master Class, International Music Masterclass of the Scuola Italiana d'Archi Mantova 2020, and in 2023 with Stefano Pagliani at the Forlì Scuola Italiana d’Archi.

She is a permanent Violin Professor at the Trento Bonporti Conservatorium.

She is a member of several Contest Juries.

Patrizia Bettotti plays a beautiful Josef Klotz and a valuable Antonio Pandolfi from 1730.